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Posts Tagged ‘molecular biology’

The Deep Sequencing Group at the Biotechnology Center of the TU
Dresden searches a highly motivated

PhD candidate

with interest in cancer genetics and technology development. The EU
funded project is focussing on the development of methods for the
transcriptome analysis of few down to single cells using next
generation sequencing technology.
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In the department of Isotope Biogeochemistry at the Helmholtz Centre for Environmental Research – UFZ we offer a position as

PhD Student in the field of anaerobic biochemistry / microbiology (code-digit 09/2011)

to commence at the earliest date. The appointment is for 3 years, working place is the Helmholtz Centre in Leipzig, Germany.

The project investigates the biochemistry of anaerobic respiration in bacteria of the genus Dehalococcoides. These bacteria are widely distributed in nature and are able to transform highly toxic, halogenated compounds by using them as electron acceptors in an anaerobic respiration. The goals of our research is to understand electron transport pathways leading to energy conservation in these bacteria and to identify the involved proteins. Preliminary results coming from microbiological, biochemical and genomic studies suggest a novel process. We anticipate to contribute with our research to the further development of bioremediation efforts and to identify biotechnological applications.

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We are seeking a candidate with a strong background in cell physiology and molecular biology with a diploma or masters degree in biology/physiology/cell biology for a PhD-thesis to work on patho-physiological mechanisms of hypoxia- and inflammation-induced pulmonary edema will be investigated.

Methods: Functional and molecular studies will be performed on a co-culture system of primary alveolar epithelial cells with lung micro-vascular endothelial cells (in vitro model of the alveolar barrier). Inflammatory processes will be initiated by adding stimulated alveolar macrophages. Rat lung barrier function will also be studied in vivo.
Signaling mechanisms will be studied by gene silencing/overexpression and functional measurements.

Time: About 3 to 4 years
Begin: January 2010

Achievements: The results of this study will help understand molecular mechanisms that cause lung epithelial and endothelial damage and edema formation in inflammation and hypoxia. These are involved in immune-defense mechanisms such as in pneumonia, ARDS, ALI. Molecular studies will help clarify involved signalling pathways.

Prof.Dr.Heimo Mairbäurl
heimo.mairbaeurl@med.uni-heidelberg.de
Medical Clinic VII, Sports Medicine
INF 410, Heidelberg, Germany

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The Children´s Hospital of the Ulm University Hospital is inviting applications for an excellent, highly motivated PhD student in the field of cancer research/apoptosis.

In a multidisciplinary and international research group (group leader: Prof. Simone Fulda), we are studying apoptosis signaling in cancers to identify key molecules that regulate apoptosis in cancer cells.

We aim at translating our knowledge into the development of new cancer therapeutics and novel prognostic biomarkers with a focus on malignant brain tumors (e.g. see FASEB J, 2009, 23:21-33; Cancer Res, 2008, 68:7956-65; Oncogene, 2008, 27:5169-81; Cancer Res, 2008, 68:6271-80; Nat Med, 2002, 8:808-15). Techniques include retroviral gene transfer, siRNA technology, cell & molecular biology, biochemistry, microscopy, primary tumor samples and mouse tumor models.

Benefits:

* The position will be paid according to established scales for PhD students (TV-L/E13, 50%, i.e. roughly 1000 EUR net salary per month).

* Successful applicants have the opportunity to participate in several (inter)national research networks on apoptosis that are coordinated by the project leader, e.g. an EU-funded Marie Curie Research Training Network, a network funded by the German Federal Ministry for Education and Research, and a clinical research group funded by the German Research Foundation.

* Our PhD program – the International Graduate School in Molecular Medicine Ulm – is funded by the Excellence Initiative of the German federal and state governments. This initiative was established in 2005 to grant competitive awards to the best performing German universities.

* The position can be filled immediately for 3 years with the possibility to extend.

Strict Requirements:
* skills in cell and molecular biology
* very good command of English language
* M.Sc. degree (or equivalent) in a highly relevant field (e.g. molecular biology). Candidates with degrees in biotechnology, human or veterinary medicine, bioinformatics, pharmacy and other distantly related areas are not considered, unless they demonstrate experience in apoptosis research.
* Your highest degree must have an average grade of at least 2.0 (in the German grading system) or an equivalent foreign grade (e.g. UK: 80%; France: 17; Italy: 52; India: 78%).
* Candidates from overseas can only be considered if they are able to attend a job interview in Germany. Unfortunately we cannot offer travel refund.

The University of Ulm aims to increase the number of women among the faculty staff and therefore explicitly encourages the application of female scientists.

Application Procedure:
* Your application should at least include your CV, the average grade of your highest degree and 2 references (name, e-mail, phone).
* Please send your application until July 31, 2009 to the assistant of Professor Fulda: nicolas.marschall@uniklinik-ulm.de
* Incomplete applications and applicants not fulfilling the requirements can unfortunately not be considered.
* Late applications are possible, since there are additional positions available regularly.
* Receipt of applications will be confirmed on request only.

If you are interested in cancer research and apoptosis and want to benefit from a cutting-edge research project combined with a structured, interdisciplinary and transeuropean training program, that’s your chance!

Ulm University is an equal opportunity employer and welcomes applications from all qualified individuals.

—————————————————————-

Von:

Nicolas Marschall
nicolas.marschall@uniklinik-ulm.de
Uniklinik für Kinder- und Jugendmedizin
Ulm

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A PhD position is available for a research project on the dissection of the neuronal circuits controlling central pain for students with a strong background in Neuroscience or Molecular Biology. Candidates should be highly enthusiastic and motivated to learn new techniques and contribute to new experiments.

Our group is interested in understanding specific neuronal cell populations and their ionic currents in defined neuronal circuits in the mouse nervous system. We use novel genetic methods to manipulate ionic currents in vivo in combination with electrophysiology and behavioral approaches.

The research work will be conducted at the Max Delbrück Center in Berlin, Germany, within the framework of the MolNeuro Research PhD School. The position is available from September 2009

Please send curriculum vitae, cover letter and the name, address and email of two references to Dr. Ines Ibañez-Tallon, Molecular Neurobiology Group, Max-Delbrück-Center, Robert-Rössle-Str. 10, D-13125 Berlin, Germany, ibanezi@mdc.berlin-de.

Ines Ibanez-Tallon
ibanezi@mdc-berlin.de
Max Delbrück Center for Molecular Medicine (MDC)
Berlin, Germany

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The Max Planck Institute for Molecular Genetics is an international research institute with approx. 470 employees, working in the field of medical genomics. A special focus lies on genome analysis of man and other organisms.

The “Genetic Variation, Haplotypes & Genetics of Complex Disease” Group is seeking a strongly motivated

Postdoctoral Scientist / Molecular Biology & Genetics
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